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Image Search Results
Journal: The Febs Journal
Article Title: In vivo modeling of lethal congenital contracture syndrome 1 suggests pathomechanisms in cellular stress responses
doi: 10.1111/febs.70195
Figure Lengend Snippet: Functional analysis of Gle1 PFQ/PFQ adult heart. (A) Representative images of ECG recordings from adult males (8 weeks old). The prolonged QRS wave duration is highlighted by red line. Mean ± SD are plotted, as well as individual data points generated from each mouse (wild‐type, WT males: 5, Gle1 PFQ/PFQ males: 3). Two‐tailed Student's t ‐test. (B) Measurement of left ventricle stroke volume via echocardiography recordings in adult (17–25 weeks old) males and females (WT males: 11, Gle1 PFQ/PFQ males: 8, WT females: 10, Gle1 PFQ/PFQ females: 9). Two‐tailed Student's t ‐test. Mean ± SD are plotted. (C) Comparison of heart weight normalized to body weight in adult (17–25 weeks old) males and females (WT males: 8, Gle1 PFQ/PFQ males: 6, WT females: 7, Gle1 PFQ/PFQ females: 7). Two‐tailed Student's t ‐test. Mean ± SD are plotted. (D) Representative images from electron microscope analysis of adult mouse left ventricular samples. Arrowheads denote damaged mitochondria (WT females: 3, Gle1 PFQ/PFQ females: 3). Original magnifications: 6800×. Scale bar: 1 mm. Mean ± SD are plotted.
Article Snippet: E16.5 heart ventricle whole‐mounts were imaged by the
Techniques: Functional Assay, Generated, Two Tailed Test, Comparison, Microscopy